Cheap Cialis 20 Mg to as psychological distress and an elevated risk of premature mortality 1 2 cardiovascular disease 3 4

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IntroductionA series of studies have shown an association between symptoms of depression and anxiety (commonly referred to as psychological distress) and an elevated risk of premature mortality,1 2 cardiovascular disease,3 4 5 6 and potentially all cancers,7 although these are not universal observations.8 9 Prospective studies investigating these associations have generally been small in scale, with only two studies reporting more than 1000 disease events.10 11 Smaller studies lead to unreliable estimates of risk, do not permit detailed investigation of the effect of reverse causality, and hamper insights into the association across the full range of psychological distress severity. Investigation of the role of reverse causality the possibility that the early stages of disease (for example, chest pain) might cause psychological distress requires large numbers of participants and events to have a sufficiently large sample after individuals with existing illness or deaths in the early phases of follow up are excluded.

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